People with chronic kidney disease (CKD) are generally advised not to take nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen), with the exception of aspirin for cardiovascular indications.
NSAIDs have been associated with acute kidney injury in the general population and with progression of disease in those with CKD. NSAIDs may also decrease the effectiveness of certain medications, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) that are often used by people with kidney disease to lower their blood pressure and protect their kidney function.